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Publikationer

Proteiner producerade vid MPE core facility sedan starten 2004 har använts i olika studier som lett till publikationer av följande vetenskapliga arbeten:

2018


Nyström EEL, Birchenough GMH, van der Post S, Arike L, Gruber AD, Hansson GC, Johansson MEV: Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity. EBioMedicine. (2018) 33:134-143. doi: 10.1016/j.ebiom.2018.05.031.


Cervin J, Wands AM, Casselbrant A, Wu H, Krishnamurthy S, Cvjetkovic A, Estelius J, Dedic B, Sethi A, Wallom KL, Riise R, Bäckström M, Wallenius V, Platt FM, Lebens M, Teneberg S, Fändriks L, Kohler JJ, Yrlid U: GM1 ganglioside-independent intoxication by Cholera toxin. PLoS Pathog. (2018) Feb 12;14(2):e1006862. doi: 10.1371/journal.ppat.1006862


Trillo-Muyo S, Nilsson HE , Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bähr A, Klymiuk N, Wine JJ, Koeck PJB, Thornton DJ, Hebert H, Hansson GC: Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers. J Biol Chem. (2018) Apr 13;293(15):5746-5754. doi: 10.1074/jbc.RA117.001014.

 

2017


Berglund AK, Navarrete C, Engqvist MKM, Hoberg E, Szilagyi Z, Taylor RW, Gustafsson CM, Maria Falkenberg M and Clausen AR: Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial DNA: PLOS Genetics (2017) http://dx.doi.org/10.1371/journal.pgen.1006628

 

2016


Bergström JH, Birchenough GMH, Katona G, Schroeder BO, Schütte A, Ermund A, Johansson MEV and Hansson GC: Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc Natl Acad Sci U S A. (2016) Nov 29;113(48):13833-13838.

Recktenwald CV and Hansson GC: The Reduction-insensitive Bonds of the MUC2 Mucin Are Isopeptide Bonds. J. Biol. Chem. (2016) 291: 13580-. doi:10.1074/jbc.M116.726406

 

2014


Nilsson HE, Ambort D, Bäckström M, Thomsson E, Koeck PJB, Hansson GC and Hebert H: Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly. J Mol Biol (2014) 54(2):250-6


2013

van der Post S, Subramani DB, Bäckström M, Johansson MEV, Vester-Christensen MB, Mandel U, Bennett EP, Clausen H, Dahlén G, Sroka A, Potempa J, and Hansson GC: Site-specific O-glycosylation on the MUC2 mucin inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB) J Biol Chem (2013), 10.1074/jbc.M113.459479

Bäckström M, Ambort D, Thomsson E, Johansson MEV and Hansson GC: Increased understanding of the biochemistry and biosynthesis of MUC2 and other gel-forming mucin O-glycoproteins, through the recombinant expression of their protein domains. Mol Biotechnol (2013) 54(2):250-6


2012

B Wizel, K Thörn, E Nagy and AM Harandi: Nasal and skin delivery of IC31®-adjuvanted recombinant HSV-2 gD protein confers protection against genital herpes. Vaccine (2012) 30:4361-4368


Ambort D, Johansson ME, Gustafsson JK, Nilsson HE, Ermund A, Johansson BR, Koeck PJ, Hebert H, Hansson GC: Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin. Proc Natl Acad Sci U S A. (2012) Apr 10;109(15):5645-50


Behnen P, Davis E, Delaney E, Frohm B, Bauer M, Cedervall T, O’Connell D, Åkerfeldt K and Linse S: Calcium-dependent interaction of calmodulin with Human 80S ribosomes and polyribosomes. Biochemistry (2012) 51:6718-6727


Chunseng J, Hultgård Ekwall AK, Bylund J, Björkman L, Estrella RP, Whitelock JM, Eisler T, Bokarewa M and Karlsson NG: Human synovial lubricin expresses sialyl Lewis X determinant and has L-selectin ligand activity. J Biol Chem (2012) 287:35922-35933


Wegmann F, Gartlan KH, Harandi AM, Brinckmann SA, Coccia M, Hillson WR, Kok WL, Cole S, Ho LP, Lambe T, Puthia M, Svanborg C, Scherer EM, Krashias G, Williams A, Blattman JN, Greenberg PD, Flavell RA, Moghaddam AE, Sheppard NC, Sattentau QJ. Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens. Nat Biotechnol. (2012) Sep;30(9):883-8

2011

Ambort D, van der Post S, Johansson ME, Mackenzie J, Thomsson E, Krengel U, Hansson G. Function of the CysD domain of the gel-forming MUC2 mucin. Biochem J. (2011) 436:61-7

Thomsson E, Persson L, Grahn A, Snäll J, Ekblad M, Brunhage E, Svensson F, Jern C, Hansson GC, Bäckström M and Bergström T: Recombinant glycoprotein E produced in mammalian cells in large-scale as an antigen for varicella-zoster-virus serology (2011) 175:53-39

A Grahn, M Studahl, S Nilsson, E Thomsson, M Bäckström, and T Bergström: Varicella-zoster virus (VZV) glycoprotein E is a serological antigen for detection of intrathecal antibodies to VZV in central nervous system infections, without cross-reaction to herpes simplex virus type-1. Clin Vaccine Immunol (2011) 18:1336-1342

2010

AR Moslemi, C Lindberg, J Nilsson, H Tajshargi, B Andersson and A Oldfors: Glycogenin-1 deficiency and inactivated priming of glycogen synthesis. N Engl J Med (2010) 362:1203-10

2009

C Sihlbom, I van Dijk Härd, ME Lidell, T Noll, GC Hansson and M Bäckström: Localisation of O-glycans in recombinant MUC1 glycoproteins using electron-capture dissociation fragmentation mass spectrometry. Glycobiology (2009) 19:375-381

Lindqvist M, Persson J, Thörn K, Harandi AM. The mucosal adjuvant effect of alpha-galactosylceramide for induction of protective immunity to sexually transmitted viral infection. J Immunol. (2009) 182:6435-43

SE Domino, EA Hurd, KA Thomsson, DM Karnak, JM Holmén Larsson, E Thomsson, M Bäckström and GC Hansson: Cervical mucins carry α1,2 fucosylated glycans that partly protect from experimental vaginal candidiasis. Glycoconjugate J (2009) 26:1125-1134

J Del Campo, M Lindqvist, J Persson, M Bäckström, O Cabrerra, M Cuello, O Perez and AM Harandi: Intranasal immunization with a proteoliposome-derived cochleate containing recombinant gD protein confers protective immunity against genital herpes in mice. Vaccine (2009) 28:1193-1200

J Persson, M Bäckström, H Johansson, K Jirström, M Fernö, GC Hansson and M Ohlin: Molecular evolution of specific human antibody against MUC1 mucin results in improved recognition of the antigen on tumor cells. Tumour Biol (2009) 30(4):221-231

2007

E. Saeland, S. van Vliet, M. Bäckström, V.C.M. van den Berg, T.B.H. Geijtenbeek and Y. van Kooyk: The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma. Cancer Immunol Immunother (2007) 56:1225-1236

Kontaktinformation

MPE core facility

Box 440, 405 30 Göteborg

Besöksadress:
Medicinaregatan 9A, sut. vån.

Telefon:
031-7863496

Fax:
031-416108

Sidansvarig: Malin Bäckström|Sidan uppdaterades: 2018-08-10
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